miR-126 and miR-126*: New Players in Cancer
نویسندگان
چکیده
منابع مشابه
MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium
Leukocyte adhesion to brain endothelial cells, the blood-brain barrier main component, is a critical step in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (MS). Leukocyte adhesion is mediated mainly by selectins, cell adhesion molecules and chemokines induced by pro-inflammatory cytokines such as TNFα and IFNγ, but the regulation of this process is not fully clear. T...
متن کاملAssociation of miR-21, miR-126 and miR-605 gene polymorphisms with ischemic stroke risk
We investigated whether three common microRNA polymorphisms (miR-21T>C [rs1292037], miR-126G>A [rs4636297] and miR-605T>C [rs2043556]) were associated with ischemic stroke (IS) risk in a Chinese population. The study population comprised 592 ischemic stroke patients and 456 normal controls. The polymorphisms were measured using Snapshot SNP genotyping assays and confirmed by sequencing. Relativ...
متن کاملmiR-126 regulates angiogenic signaling and vascular integrity.
Precise regulation of the formation, maintenance, and remodeling of the vasculature is required for normal development, tissue response to injury, and tumor progression. How specific microRNAs intersect with and modulate angiogenic signaling cascades is unknown. Here, we identified microRNAs that were enriched in endothelial cells derived from mouse embryonic stem (ES) cells and in developing m...
متن کاملSimultaneous overexpression of miR-126 and miR-34a induces a superior antitumor efficacy in pancreatic adenocarcinoma
Background Pancreatic adenocarcinoma (PAC) is one of the most fatal cancers due to its high degree of malignancy, increasing incidence, high mortality, and unsatisfactory treatment efficacy. Evidence has suggested that numerous microRNAs (miRNAs), including miR-126 and miR-34a, have potent tumor-suppressing effects on PAC, implicating a possible application of miRNA in tumor therapy. However, t...
متن کاملCirculating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans
BACKGROUND Recently, plasma miRNAs have been reported as biomarkers for various diseases. However, the knowledge on the association of plasma miRNAs with ischemic stroke is still lacking. In this study, we investigated whether plasma concentrations of miR-30a, miR-126 and let-7b may be biomarkers for ischemic stroke in humans. METHODS One hundred ninety seven patients with ischemic stroke wer...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2010
ISSN: 1537-744X
DOI: 10.1100/tsw.2010.198